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Where on Chromosome is Problem?

"Congenital generalized hypertrichosis (CGH) is a rare, X−linked dominant trait. CGH is a visually striking phenotype characterized by excessive facial and upper torso hair in males and by less severe asymmetric hairiness in females. Evidence shows linkage with several markers from the long arm of the X chromosome. Recombinant chromosomes place theCGH gene within a 22 cM interval between DXS425 and DXS1227 in Xq24−Xq27.1. The localization of a gene for CGH represents the first step towards the isolation of genes involved in hair growth pattern, particularly those involved in restriction of areas in humans."

This kind of seems like ridiculous mumbo jumbo, so I'll tell you that Congenital Terminal Hypertrichosis origininates on the 17th chromosome, and seems to be a result of not one missing nucleotide but millions.

What Is the problem?

Congenital Hypertrichosis results in one major symptom: excessive growth of hair all over the body. For this reason, it is sometimes known as "Wolfman Disease" or "Werewolf Disease," perhaps rather insensitively. The only areas of the body not affected by excessive hair are the soles of the feet, palms of the hand, and the mucous membranes in your nose. Luckily enough, these are the only symptoms, so you can look awesome and as werewolfish as can be and still lead a full, healthy and productive life.

There are multiple types of Hypertrichosis, but we can split the various types into two categories: congenital and acquired. Congenital Hypertrichosis can be even further split up into various different genetic abnormalities, some with probems on the 8th chromosome and some with problems on the 17th. The kind of Hypertrichosis that results in hair growth all across the body is Congenital Terminal Hypertrichosis.

What is the Prognosis?

Fortunately, CGH is not a fatal disease and simply causes excessive hair growth on certain parts of the body which can vary. In the womb, a normal child will have lanugo hair all around their body, and then shed eight months in an replace it with vellus hair in preparation for birth. However a child with CGH will be unable to shed their lanugo hair in the womb and simply keep it for the rest of their life.


Cite Your Sources

http://dermnetnz.org/hair-nails-sweat/hypertrichosis.html