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Amelia and Lindaluz

Where on Chromosome is Problem?

Cri du chat syndrome occurs due to a missing piece or a deletion on the short arm of chromosome number five. Because of this, multiple genes are missing as a result of this deletion which may contribute to the symptoms of the disorder. It affects between 1 in 20,000 and 1 in 50,000 babies.

What Is the Problem?

Most cases are believed to occur during the development of the egg or sperm. A small number of cases occur when a parent passes a different, rearranged form of the chromosome onto their child
  • Cry that is high-pitched and sounds like a cat
  • Downward slant to the eyes
  • Low birth weight and slow growth
  • Low-set or abnormally shaped ears
  • Intellectual disability
  • Partial webbing or fusing of fingers or toes
  • Single line in the palm of the hand
  • Skin tags just in front of the ear
  • Slow or incomplete development of motor skills
  • Small head (microcephaly)
  • Small jaw (micrognathia)
  • Wide-set eyes

What is the Prognosis?

Intellectual disability is common. Half of children with this syndrome learn enough verbal skills to communicate. The cat-like cry becomes less noticeable over time but as they grow, they usually have difficulty walking and talking correctly.

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